Elamipretide (SS-31)

Inoa ʻē aʻe: SS-31; Elamipretide; MTP-131; Bendavia
CAS NO .: 736992-21-5
Palapala Molecular: C32H49N9O5
Molecular Weight: 639.802
Nānā: Pada Keʻokeʻo
Maʻemaʻe (HPLC): 99.0%

Launch
1. E hoʻomaikaʻi i ka hana mitochondrial a me ka hana ikehu, hiki ke alakaʻi i ka ikaika o ka ʻiʻo a me ka hoʻemi ʻana i ka luhi;
2. Hoʻomaikaʻi i ka hana naʻau a me ka ikaika o ka ʻiʻo i nā poʻe me ka maʻi Barth ma o ka huli ʻana i ka mitochondrial dysfunction;
3. Hoʻomaikaʻi i ka hana naʻau a me ka hōʻemi ʻana i nā hōʻailona i nā poʻe me ka puʻuwai puʻuwai;

ʻO ka wehewehe e pili ana iā Elamipretide (SS-31)
ʻO Elamipretide, ʻike ʻia ʻo SS-31, MTP-131, kahi pūhui peptide liʻiliʻi i hoʻomohala ʻia e Stealth BioTherapeutics. Ke noiʻi ʻia nei no kāna mau noi therapeutic kūpono i nā maʻi a me nā kūlana mitochondrial.
ʻO Elamipretide kahi peptide i hoʻopaʻa ʻia i ka mitochondria e manaʻo nei e hoʻomaikaʻi i ka hana mitochondrial. ʻO Mitochondria nā hale mana o nā cell, kuleana no ka hana ʻana i ka ikehu ma ke ʻano o ATP. Hoʻolālā ʻia ʻo Elamipretide e komo i ka mitochondria a hui pū me ka cardiolipin, kahi mea nui o ka membrane mitochondrial i loko. Ma ka hoʻokūpaʻa ʻana i ka cardiolipin a me ka hoʻomaikaʻi ʻana i kāna hana, manaʻo ʻo elamipride e hoʻonui i ka ikehu mitochondrial a hoʻemi i ke kaumaha oxidative.
Ua noiʻi ʻia ʻo Elamipretide no kāna mau hoʻohana lapaʻau kūpono i nā maʻi mitochondrial like ʻole, me ka myopathy mitochondrial mua, Barth syndrome, a me Leber's hereditary optic neuropathy (LHON). Hōʻike ʻia kēia mau kūlana e ka hana mitochondrial impaired a me ka hana ikehu. Ke manaʻo nei ʻo Elamipretide e hoʻomaikaʻi i ka hana mitochondrial, hiki ke alakaʻi i ka ikaika o ka ʻiʻo, hoʻemi i ka luhi, a me nā hopena maikaʻi ʻē aʻe.